Explore a gene
Enter a human gene symbol to see where disease-linked protein changes sit in the AlphaFold 3D structure, how confident that structure is, and how rare the changes are in the general population.
Your saved genes
Gene overview
3D structure
- Pathogenic variants within 10 residues: none (light) to many (dark)
- Pathogenic / likely pathogenic (red spheres)
- Benign / likely benign (green, optional)
- VUS / conflicting (gray, optional)
Text version of the 3D view
Variants along the protein
- Pathogenic (circle) / likely pathogenic (triangle) above the line
- Benign (circle) / likely benign (triangle) below the line
- Height = −log10(gnomAD allele frequency), capped. Absent from gnomAD = full height. Hollow = frequency unknown.
- Drag across the plot to zoom. The strip under the axis shows AlphaFold pLDDT.